Is "anmède" an appropriate word in nice company?

Sure.

There's nothing vulgar about it.

It does have a slight similarity to "nan mèd" which is a vulgar expression.

The pronunciation is different too.

anmède (v.) → to bother, to inconvenience, to irritate, to badger

anmèdan (n.) → bully, teaser, jokester, pain in the neck

Poukisa w'ap anmède m konsa?

Why are you giving me such a headache?

Mwen pat vle travay pandan sezon fèt la, men patwon mwen anmède m jiskaske mwen asepte.

I didn't want to work during the holidays, but my boss nagged me until I said yes.

Pa pran li oserye. Li se yon anmèdan.

Don't take him seriously. He's a teaser.

Other Creole synonyms for anmède (v.) are:  annniye, trakase, anbete, takinen, fann nan kò, pèsekite

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